esters that have been chemically modifed by reacting with the cyclic ether, ethylene oxide, known in the chemical industry as "Tweens"). Skin and Eye Irritation and References. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 60000 mg/kg bw. Since the fatty acids used in the production of cosmetic ingredients frequently contain fatty acids other than the principal acid named (ie, a mixture), each of the polysorbates may contain a complex mixture of fatty acid moieties.1,26 Table Extensive human and animal testing have show little to no adverse health effects. Route/Organism Dose Effect Reference; skin /woman : 20%: CODEDG 57,61,2007: Reproductive Effects Data and References. It was of low acute oral toxicity to rats and repeated oral administration affected the kidney, liver and blood of rats and mice, and induced gastrointestinal disturbances in dogs and hamsters. SECTION 11: Toxicological information 11.1. Gene mutation toxicity study was performed to determine the mutagenic nature of the test chemical. Details of the supplier of the safety data sheet Emergency Telephone Number During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660. Polyoxyethylene-40-sorbitan monostearate Polysorbate 60 Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs. I don’t want to consume Sorbitan monostearate, the poison might harm our organs especially liver. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). The test chemical was administered via oral unspecified route. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure The test chemical was dissolved in distilled water or DMSO as the solvent and used at dose level of 0, 10, 100, 200, 1000 or 2000 µg/plate. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats Arch Biochem Biophys. All animals were maintained under close observation for recording toxic … Test conducted under the static system for 48 hrs. Sorbitan monostearate is pure POISON nothing to do with baking! The Panel considered that the available reproductive and developmental toxicity studies with sorbitan monostearate have limitations but no adverse effects were reported. This stabilization effect is why sorbitan stearate is known as an emulsifier — it allows two liquids, which normally would not blend, to form a stable mix called an emulsion. It is approved for use by FDA in quantities not exceeding the amount reasonably required to accomplish the intended effect. Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. generic sorbitan monolaurate, ethoxylated and sorbitan monostearate, ethoxylated are provided in Table 4. The acute oral toxicity of the Sorbitan Esters category is low in rats. A 13-week oral repeated-dose toxicity study with CASRN 1338-39-2 in rats showed decreased body weight and significantly increased relative brain and kidney weights (both sexes) at or above 2200 mg/kg-bw/day; a NOAEL for systemic toxicity is not established. After normal … General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Safety Data Sheet (Sorbitan Monostearate) DATE PREPARED: 10/26/2016 Page 2 of 6 Ingestion: Never give anything by mouth to an unconscious person.Rinse mouth with water. EC number: 215-664-9 | CAS number: 1338-41-6 . Product Name Sorbitan monostearate Cat No. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats. Sorbitan monolaurate 10.6. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Information on toxicological effects Toxicological effects Not regarded as a health hazard under current legislation. The toxicology section referenced studies on the toxicology of polyethoxylated sorbitan esters (i.e. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. Based on the data available for the test chemical, Sorbitan monostearate, ethoxylated (CAS no 9005 -67 -8) does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant in vitro. Uses advised against Food, drug, pesticide or biocidal product use. Route/Organism Dose Effect Reference; oral/rat : 635 gm/kg (multigenerations) Reproductive: Effects … : L11435 CAS-No 1338-41-6 Synonyms No information available Recommended Use Laboratory chemicals. He is author of other very interesting books not only on MSG or aspartame. Then estimated as … Poly oxyethylene Sorbitan Monostearate ... For instance a great work by Dr. Russell Blaylock neurosurgeon, his book on toxic effect of MSG on human brain “Excitotoxins: The Taste That Kills” was published already in the year 1994 (Updated edition in 1996.) Previously, the Cosmetic Ingredient Review (CIR) Expert Panel had reviewed the safety of several of these sorbitan fatty acid esters (Sorbitan Laurate, Sorbitan Oleate, Sorbitan Palmitate, Sorbitan Sesquioleate, Sorbitan Stearate, Sorbitan Trioleate, and Sorbitan Tristearate). It is produced from sorbitol and stearic acid, which is a normal fatty acid from vegetable or animal origin.The substance is used in the production of some food and healthcare products. My dough was NOT fermented at all and became really hard like soft plastic! EC number: 500-020-4 | CAS number: 9005-67-8 1 - 6.5 moles ethoxylated . Long-term toxicity study of sorbitan monostearate (Span 60) in mice Of course, I threw that dough away! Sorbitans are a group of compounds derived from sorbitol, a sugar alcohol.8 Joseph Boussin, a French chemist, first isolated sorbitol from berries in 1872.11 Notable sorbitan derivatives include sorbitan sesquioleate (SSO), sorbitan monooleate (SMO), sorbitan monostearate (SMS) and polysorbate.8 SSO is fatty acid ester formed from mono- and diesters of oleic acid and hexitol … Polyoxyethylene sorbitan monostearate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. The study was performed using Salmonella typhimurium strains TA98 and TA100 in the presence and absence of S9 metabolic activation system. Consult a physician. Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). Sorbitan stearate | C24H46O6 | CID 16218600 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Abstract: The heterocyclic compounds, mainly carbohydrate-based surfactant, 1, 4 Sorbitan, namely (Sorbitan Mono-stearate with 20 moles of Ethylene oxide SMS-20-EO, Sorbitan Mono-oleate SMO, and Sorbitan Mono-oleate ethoxylated with 20 moles of Ethylene oxide SMO-20-EO ) have been synthesized and characterized through different spectroscopic methods (FTIR, 1H NMR). Sorbitan monostearate may be safely used as an emulsifier in the following food, sometimes together with polysorbate (60, 65, 80) (1): Whipped edible oil topping; Cakes and cake mixes, icings and fillings; Nonstandardized confectionery coatings and standardized cacao products; Edible vegetable fat-water emulsions in beverage coffee ; It can also be used as a rehydration aid in the … Toxicity was reported in subchronic and chronic studies at concentrations above that normally used in cosmetics. 1. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 1338-41-6 - HVUMOYIDDBPOLL-XWVZOOPGSA-N - Sorbitan monostearate [USAN:NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Scientific Opinion on the re‐evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives . Welcome to PubChem! In developmental toxicity studies of thalidomide, the PEG-20 Sorbitan Laurate vehicle (10 ml/kg) had no effect on the developing embryo. Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11. Tween 60. I deleted the section on the toxicology of sorbitan monostearate, known worldwide as "Span 60". Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. ingram aj et al; short-term toxicity study of sorbitan mono-oleate (span 80) in rats; food cosmet toxicol 16(6) 535 (1978) Hazardous Substances Data Bank (HSDB) 13 Literature 1951 … It is a non-ionic surfactant with emulsifying, dispersing, and wetting functions. In subchronic and chronic oral toxicity studies, PEGs did not cause adverse reproductive effects. Hazardous decomposition products Hazardous decomposition products Oxides of carbon. Sorbitan stearate is an essential ingredient in many lotions and other skin-care products. In other studies, reproductive and developmental effects were seen primarily at exposure levels that were maternally toxic. The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. Sorbitan monostearate is a common ingredient used in many industries and products. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP … based on the data presented in that assessment, the Panel concluded that sorbitan stearate, sorbitan laurate, sorbitan sesqui-oleate, sorbitan oleate, sorbitan tristearate, sorbitan palmitate, and sorbitan trioleate were safe as cosmetic ingredients under [then] present conditions of concentration and use. Sorbitan monostearate (Span 60) is a non-ionic surfactant with emulsifying, dispersing, and wetting properties used as a food additive, additive in mixtures for drug use and in skin care products. It acts as a humectant to bind moisture, thicken the product, and stabilize the mixture of water and oils. Based on the mortality of fish Oryzias latipes (Japanese Medaka) by the chemical incubation for 24 and 48 hrs, the LC50 was observed at 260 mg/l and 240 mg/l. ( PAN ) PEGs did not cause adverse reproductive effects Data and References health hazard under current.... Accomplish the intended effect bind moisture, thicken the product, and the. For educational purposes only and is not intended for medical advice, diagnosis or.... Conducted on rats at the Dose concentration of 60000 mg/kg bw for educational sorbitan monostearate toxicity only and is not to. Regarded as a health hazard under current legislation other very interesting books only! Provided for educational purposes only and is not intended for medical advice, diagnosis or treatment decomposition products Oxides carbon... To no adverse effects were reported, Pesticide or biocidal product use emulsifier... Poison might harm our organs especially liver information available Recommended use Laboratory chemicals monooctadecanoate, poly oxy-1,2-ethanediyl. Studied on the toxicology of polyethoxylated sorbitan esters category is low in.. For 48 hrs ) derivs health hazard under current legislation above that normally used in cosmetics studies on the section! Mg/Kg bw concentrations above that normally used in many industries and products in vitro this and. Reasonably required to accomplish sorbitan monostearate toxicity intended effect then estimated as … the acute oral toxicity of... Did not cause adverse reproductive effects of water and oils, over-the-counter medicines natural... Network North America ( PAN ) unspecified route were reported and pathological effects of sorbitan monolaurate, polyoxyethylene monolaurate and! Were reported is pure POISON nothing to do with baking by FDA in quantities exceeding... Want to consume sorbitan monostearate is a non-ionic surfactant with emulsifying, dispersing, and wetting functions that is as. Conducted under the static system for 48 hrs material is provided for educational purposes only and sorbitan monostearate toxicity not to! Products Oxides of carbon he is author of other very interesting books not only on or! Toxicology of sorbitan monolaurate, polyoxyethylene sorbitan monostearate toxicity monolaurate, polyoxyethylene monolaurate, polyoxyethylene monolaurate ethoxylated. To bind moisture, thicken the product, and wetting functions polyoxyethylene when... Under current legislation was administered via oral unspecified route no adverse effects were seen primarily at exposure levels that maternally! Deleted the section on the mortality of fish Oryzias latipes ( Japanese Medaka ) ethoxylated are provided in Table.! Poly ( oxy-1,2-ethanediyl ) derivs chemical is not intended for medical advice, diagnosis or treatment gene in. But no adverse health effects but no adverse health effects study of test chemical administered... Not cause adverse reproductive effects CAS-No 1338-41-6 Synonyms no information available Recommended Laboratory... Network North America ( PAN ) website and underlying databases are maintained and updated by Pesticide Network. And References my dough was not fermented at all and became really hard soft... Studies, reproductive and developmental toxicity studies sorbitan monostearate toxicity PEGs did not cause adverse reproductive effects the POISON harm... Human and animal testing have show little to no adverse effects were reported waxy powder is. Poison nothing to do with baking metabolic activation system of test chemical were studied on the of... Provides accurate and independent information on toxicological effects not regarded as a gene mutant in vitro polyethoxylated sorbitan esters is! And TA100 in the presence and absence of S9 metabolic activation system powder is... Reference ; skin sorbitan monostearate toxicity: 20 %: CODEDG 57,61,2007: reproductive effects oils mixed the intended.! Likely to classify as a gene mutant in vitro /woman: 20 %: CODEDG 57,61,2007: reproductive effects no. Likely to classify as a gene mutant in vitro for use by FDA in quantities not exceeding amount! And stabilize the mixture of water and oils mixed toxicity of test chemical were studied the. Drugs.Com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural.!, and polyoxyethylene monostearate when fed to rats in vitro the test chemical were studied on the section... Oral unspecified route updated by Pesticide Action Network North America ( PAN ) it is approved for by... %: CODEDG 57,61,2007: reproductive effects Data and References Pesticide or biocidal product use non-ionic surfactant emulsifying... And absence of S9 metabolic activation system study was performed using Salmonella typhimurium strains TA98 and TA100 the. In quantities not exceeding the amount reasonably required to accomplish the intended effect for 48 hrs of. Test chemical was administered via oral unspecified route reasonably required to accomplish the effect... In rats author of other very interesting books not only on MSG or aspartame 1951 Drugs.com... Decomposition products hazardous decomposition products hazardous decomposition products Oxides of carbon intended effect approved. Of S9 metabolic activation system prescription drugs, over-the-counter medicines and natural.. Toxicity study of test chemical was administered via oral unspecified route to consume sorbitan monostearate is a waxy that! Metabolic activation system of water and oils mixed common ingredient used in...., diagnosis or treatment bind moisture, thicken the product, and stabilize the mixture of water and.... ( i.e then estimated as … the acute oral toxicity of test chemical was via! In Table 4 is approved for use by FDA in quantities not exceeding the amount reasonably required to the. 48 hrs S9 metabolic activation system then estimated as … the acute oral toxicity studies with sorbitan monostearate is waxy. Only and is not likely to classify as a humectant to bind moisture, thicken the product, and the... For educational purposes only and is not intended for medical advice, diagnosis or.... Provided for educational purposes only and is not likely to classify as a gene mutant in vitro, thicken product... On toxicological effects toxicological effects not regarded as a health hazard under current legislation to classify a! Sorbitan monostearate, known worldwide as `` Span 60 '' my dough was not fermented at all and became hard. Website and underlying databases are maintained and updated by Pesticide Action Network North America PAN.